Title : Noncarbohydrate glycomimetics and glycoprotein surrogates as DC-SIGN antagonists and agonists.

Pub. Date : 2012 Sep 21

PMID : 22747463






2 Functional Relationships(s)
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1 We previously reported a small molecule that embodies key features of the carbohydrates that bind DC-SIGN. Carbohydrates CD209 molecule Homo sapiens
2 Using NMR HSQC experiments, we found that the compound mimics saccharide ligands: It occupies the same carbohydrate-binding site and interacts with the same amino acid residues on DC-SIGN. Carbohydrates CD209 molecule Homo sapiens