Title : Binding of N-acetylglucosamine (GlcNAc) β1-6-branched oligosaccharide acceptors to β4-galactosyltransferase I reveals a new ligand binding mode.

Pub. Date : 2012 Aug 17

PMID : 22740701






1 Functional Relationships(s)
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1 Here we report seven crystal structures of beta4Gal-T1 in complex with an oligosaccharide acceptor with a nonreducing end GlcNAc that has a beta1-6-glycosidic link and that are analogous to either N-glycan or i/I-antigen. Oligosaccharides UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens