Title : Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells.

Pub. Date : 2012 Dec

PMID : 22740037






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-kappaB activation in TPA-induced breast cancer cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
2 In the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase (MMP)-9 and cyclooxygenaase-2 (COX-2) in breast cancer cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
3 In the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase (MMP)-9 and cyclooxygenaase-2 (COX-2) in breast cancer cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
4 Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
5 These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens