Title : Amlodipine, clopidogrel and CYP3A5 genetic variability: effects on platelet reactivity and clinical outcomes after percutaneous coronary intervention.

Pub. Date : 2012 Sep

PMID : 22735685






2 Functional Relationships(s)
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1 Amlodipine is a well-known inhibitor of CYP 3A4, an isoenzyme of CYP3A that activates clopidogrel. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In the presence of CYP3A4 inhibitors such as amlodipine, the genetic variation of CYP3A5, the isoenzyme responsible for the backup CYP3A activity, may play an important role in clopidogrel activation. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens