Title : Ascorbic acid rescues cardiomyocyte development in Fgfr1(-/-) murine embryonic stem cells.

Pub. Date : 2013 Jan

PMID : 22735182






2 Functional Relationships(s)
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1 We treated mESC with Fe(2+) or the HIF inhibitor CAY10585 during the first phases of the differentiation process and, similar to vitC, the two compounds were able to rescue cardiomyocyte formation in Fgfr1(-/-) mESC, thus implicating HIF-1alpha modulation in Fgfr1-dependent cardiomyogenesis. ammonium ferrous sulfate fibroblast growth factor receptor 1 Mus musculus
2 We treated mESC with Fe(2+) or the HIF inhibitor CAY10585 during the first phases of the differentiation process and, similar to vitC, the two compounds were able to rescue cardiomyocyte formation in Fgfr1(-/-) mESC, thus implicating HIF-1alpha modulation in Fgfr1-dependent cardiomyogenesis. ammonium ferrous sulfate fibroblast growth factor receptor 1 Mus musculus