Title : Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.

Pub. Date : 2012 Jul 17

PMID : 22730894






2 Functional Relationships(s)
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1 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. Phosphatidylcholines apolipoprotein E Homo sapiens
2 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. Phosphatidylcholines apolipoprotein E Homo sapiens