Pub. Date : 2012 Nov
PMID : 22717288
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of SIRT1 or SIRT1 activation by resveratrol obviously attenuated the expression of CD40 induced by TNF-alpha in 3T3-L1 adipocytes, whereas knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol significantly enhanced TNF-alpha-induced expression of CD40. | Niacinamide | tumor necrosis factor | Homo sapiens |
| 2 | Furthermore, overexpression of SIRT1 or SIRT1 activation by resveratrol diminished TNF-alpha-induced acetylation of NF-kappaBp65, while knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol augmented TNF-alpha-induced acetylation of NF-kappaBp65 in 3T3-L1 adipocytes. | Niacinamide | tumor necrosis factor | Homo sapiens |