Title : Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase.

Pub. Date : 1990 Nov 20

PMID : 2271666






2 Functional Relationships(s)
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1 The 2-substituted acyl-CoA analogues, 2-hydroxymyristoyl-CoA, 2-bromomyristoyl-CoA, and 2-fluoromyristoyl-CoA, were synthesized and shown to be competitive inhibitors of NMT in vitro (Ki"s = 45, 450, and 200 nM, respectively). Acyl Coenzyme A N-myristoyltransferase 1 Homo sapiens
2 Of the three acyl-CoA analogues, only 2-fluoromyristoyl-CoA served as a substrate for NMT. Acyl Coenzyme A N-myristoyltransferase 1 Homo sapiens