Title : Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis.

Pub. Date : 2012 Jul 6

PMID : 22713471






1 Functional Relationships(s)
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1 The results showed that nicotine neutralized the effect of IL-1beta on chondrocytes by activating PI3K/Akt signaling pathways, including the PI3K/Akt/Bcl-2 pathway, to block IL-1beta-induced cell apoptosis and the PI3K/Akt/p70S6K (p70S6 kinase)/S6 pathway for promoting protein synthesis, modulating its downstream effectors such as TIMP-1 and MMP-13. Nicotine ribosomal protein S6 kinase B1 Rattus norvegicus