Title : Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.

Pub. Date : 2013 Jan

PMID : 22711601






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1 Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens
2 Using human B-cell lymphoma models and MRS, we have demonstrated that the inhibition of the mTOR signaling pathway can be detected in malignant cells in vitro and noninvasively in vivo by the measurement of lactate levels. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens
3 An mTOR inhibitor, rapamycin, suppressed lactic acid production in lymphoma cell line cultures and also diminished steady-state lactate levels in xenotransplants. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens
4 An mTOR inhibitor, rapamycin, suppressed lactic acid production in lymphoma cell line cultures and also diminished steady-state lactate levels in xenotransplants. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens