Title : κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.

Pub. Date : 2012 Oct

PMID : 22709632






1 Functional Relationships(s)
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1 kappa-Opioid receptors (KOPr; encoded by OPRK1), and their endogenous agonists, the dynorphins (encoded by PDYN), have counter-modulatory effects on reward caused by cocaine or MOPr agonist exposure, and exhibit plasticity in addictive-like states. Cocaine opioid receptor kappa 1 Homo sapiens