Title : Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.

Pub. Date : 2012 Jul 24

PMID : 22689948






1 Functional Relationships(s)
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1 In human lymphoblasts, NRG1-mediated phosphatidyl-inositol,3,4,5 triphosphate [PI(3,4,5)P3] signaling is predicted by schizophrenia-associated ErbB4 genotype and PIK3CD levels and is impaired in patients with schizophrenia. Phosphatidylinositols phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens