Pub. Date : 1990 Dec 1
PMID : 2268367
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition by manoalide of fMLP-stimulated elastase release from human neutrophils. | manoalide | formyl peptide receptor 1 | Homo sapiens |
| 2 | To understand the mechanism of this inhibition, we examined the effect of manoalide on the signal-transduction pathway believed to mediate fMLP stimulation. | manoalide | formyl peptide receptor 1 | Homo sapiens |
| 3 | We observed in fura-2 loaded cells that pretreatment with manoalide blocked fMLP-induced increases in cytosolic free-calcium (IC50 approximately 0.15 microM). | manoalide | formyl peptide receptor 1 | Homo sapiens |