Pub. Date : 2012 Oct
PMID : 22683417
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore the possible involvement of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP)1, MRP2, MRP3, and breast cancer resistance protein in the observed high interindividual variability. | Raloxifene Hydrochloride | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore the possible involvement of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP)1, MRP2, MRP3, and breast cancer resistance protein in the observed high interindividual variability. | Raloxifene Hydrochloride | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Caco-2 cell monolayer experiments indicated an interaction of raloxifene with Pgp. | Raloxifene Hydrochloride | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The ATPase assay confirmed the raloxifene interaction with Pgp and indicated interactions of all raloxifene species with MRP1, MRP2, MRP3, and breast cancer resistance protein, except for M1, which did not show any interactions with MRP2. | Raloxifene Hydrochloride | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The results of our study support the involvement of efflux transporters in disposition of raloxifene and its metabolites and may partially explain the observed raloxifene variability by the influence of the ABCB1 c.3435C>T polymorphism. | Raloxifene Hydrochloride | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The results of our study support the involvement of efflux transporters in disposition of raloxifene and its metabolites and may partially explain the observed raloxifene variability by the influence of the ABCB1 c.3435C>T polymorphism. | Raloxifene Hydrochloride | ATP binding cassette subfamily B member 1 | Homo sapiens |