Title : Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19-TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma.

Pub. Date : 2013 Feb

PMID : 22674435






1 Functional Relationships(s)
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1 CONCLUSIONS: ILP with L19-TNF had a favorable safety and a promising activity profile at a dose of 650 microg of L19-TNF, supporting the exploration of higher L19-TNF doses and a Phase II trial comparing L19-TNF ILP with standard melphalan-containing ILP. Melphalan tumor necrosis factor Homo sapiens