Title : TNF-α modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes.

Pub. Date : 2012 Oct

PMID : 22658637






1 Functional Relationships(s)
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1 CONCLUSIONS: Our findings suggested that simvastatin counteracted the stimulatory effect of TNF-alpha on secretion and expression of MCP-1, PAI-1 and adiponectin, implying a potential anti-atherogenic effect during the inflammatory process; these pleitropic effects were more pronounced with HMG-CoA reductase inhibitor. Simvastatin C-C motif chemokine ligand 2 Homo sapiens