Title : Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.

Pub. Date : 2012 May 31

PMID : 22651890






3 Functional Relationships(s)
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1 We hypothesized that any Nef-SH3 domain interactions would be lost upon mutation of the prolines or arginine of PXXPXR. Proline S100 calcium binding protein B Homo sapiens
2 RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI). Proline S100 calcium binding protein B Homo sapiens
3 RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI). Proline S100 calcium binding protein B Homo sapiens