Pub. Date : 2012 May
PMID : 22648626
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein beta activation. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | However, the influence of capsaicin on CYP3A4, its involvement in drug metabolism, and the underlying mechanisms remain unclear. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | METHODS AND RESULTS: Here, we examined the effect of capsaicin on CYP3A4 expression and the metabolism of CYP3A1 substrate, nifedipine in male Sprague-Dawley rats. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Capsaicin induced the enzymatic activity and expression of CYP3A4 in HepG2 cells. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Treatment with a human pregnane X receptor (hPXR) inhibitor reduced the inductive effects of capsaicin on CYP3A4 expression. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | CONCLUSION: From these data, we conclude that capsaicin induces CYP3A4 expression in vitro and in vivo. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 8 | Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 9 | Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 10 | Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions. | Capsaicin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |