Title : Adjunctive daptomycin attenuates brain damage and hearing loss more efficiently than rifampin in infant rat pneumococcal meningitis.

Pub. Date : 2012 Aug

PMID : 22644021






2 Functional Relationships(s)
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1 Daptomycin plus ceftriaxone versus ceftriaxone significantly (P < 0.04) lowered CSF concentrations of monocyte chemoattractant protein 1 (MCP-1), MIP-1alpha, and interleukin 6 (IL-6) at 6 h and MIP-1alpha, IL-6, and IL-10 at 22 h after initiation of therapy, led to significantly (P < 0.01) less apoptosis, and significantly (P < 0.01) improved hearing capacity. Daptomycin C-C motif chemokine ligand 3 Rattus norvegicus
2 Daptomycin plus ceftriaxone versus ceftriaxone significantly (P < 0.04) lowered CSF concentrations of monocyte chemoattractant protein 1 (MCP-1), MIP-1alpha, and interleukin 6 (IL-6) at 6 h and MIP-1alpha, IL-6, and IL-10 at 22 h after initiation of therapy, led to significantly (P < 0.01) less apoptosis, and significantly (P < 0.01) improved hearing capacity. Daptomycin C-C motif chemokine ligand 3 Rattus norvegicus