Title : Combination of low doses of enzastaurin and lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines.

Pub. Date : 2012 Oct

PMID : 22623160






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1 The combination of Enzastaurin and Lenalidomide, at doses as low as 1 muM, showed strong synergism against indolent lymphomas by reducing cell growth, producing an increase in G0-G1 phase followed by significant decrease in S phase, increasing apoptosis, and inhibiting PI3K/AKT, PKC and MAPK/ERK pathways. Lenalidomide latexin Homo sapiens