Title : Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro.

Pub. Date : 2012 Jun

PMID : 22619112






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Initial studies characterizing the metabolic capacity of proliferating lacZ primary hepatocytes indicated that these cells retained at least some activities important for xenobiotic metabolism: cytochrome P450 1A1 enzyme activities were markedly increased in the hepatocytes after exposure to benzo[a]pyrene, and also UDP-glucuronosyl transferase and glutathione-S-transferase activities, both Phase II enzymes, were detected. Benzo(a)pyrene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus