Pub. Date : 2012 Jun 5
PMID : 22615413
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that most etoposide-induced chromosome breaks in the MLL locus and the overall genotoxicity of etoposide are dependent on topoisomerase IIbeta, but that topoisomerase IIalpha and -beta occupancy and etoposide-induced DNA cleavage data suggest factors other than local topoisomerase II concentration determine specific clustering of MLL translocation breakpoints in t-AML. | Etoposide | lysine methyltransferase 2A | Homo sapiens |
| 2 | We show that most etoposide-induced chromosome breaks in the MLL locus and the overall genotoxicity of etoposide are dependent on topoisomerase IIbeta, but that topoisomerase IIalpha and -beta occupancy and etoposide-induced DNA cleavage data suggest factors other than local topoisomerase II concentration determine specific clustering of MLL translocation breakpoints in t-AML. | Etoposide | lysine methyltransferase 2A | Homo sapiens |
| 3 | We show that most etoposide-induced chromosome breaks in the MLL locus and the overall genotoxicity of etoposide are dependent on topoisomerase IIbeta, but that topoisomerase IIalpha and -beta occupancy and etoposide-induced DNA cleavage data suggest factors other than local topoisomerase II concentration determine specific clustering of MLL translocation breakpoints in t-AML. | Etoposide | lysine methyltransferase 2A | Homo sapiens |
| 4 | We show that most etoposide-induced chromosome breaks in the MLL locus and the overall genotoxicity of etoposide are dependent on topoisomerase IIbeta, but that topoisomerase IIalpha and -beta occupancy and etoposide-induced DNA cleavage data suggest factors other than local topoisomerase II concentration determine specific clustering of MLL translocation breakpoints in t-AML. | Etoposide | lysine methyltransferase 2A | Homo sapiens |