Title : Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice.

Pub. Date : 2012 Jul 15

PMID : 22611027






1 Functional Relationships(s)
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1 In tumor-bearing mice, vandetanib suppressed phosphorylation of VEGFR-2 and EGFR in tumor tissues, significantly reduced tumor vessel density, enhanced tumor cell apoptosis, suppressed tumor growth, improved survival, reduced number of intrahepatic metastases, and upregulated VEGF, TGF-alpha, and EGF in tumor tissues. vandetanib vascular endothelial growth factor A Mus musculus