Pub. Date : 2012 Dec
PMID : 22609045
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cause of SBMA is the expansion of a trinucleotide CAG repeat encoding a polyglutamine tract within the first exon of the androgen receptor (AR) gene. | polyglutamine | androgen receptor | Homo sapiens |
| 2 | The cause of SBMA is the expansion of a trinucleotide CAG repeat encoding a polyglutamine tract within the first exon of the androgen receptor (AR) gene. | polyglutamine | androgen receptor | Homo sapiens |
| 3 | The cause of SBMA is the expansion of a trinucleotide CAG repeat encoding a polyglutamine tract within the first exon of the androgen receptor (AR) gene. | polyglutamine | androgen receptor | Homo sapiens |
| 4 | The ligand-dependent nuclear accumulation of the polyglutamine-expanded AR protein is central to the gender-specific pathogenesis of SBMA, although additional steps, e.g., DNA binding, inter-domain interactions, and post-translational modification of AR, modify toxicity. | polyglutamine | androgen receptor | Homo sapiens |
| 5 | The ligand-dependent nuclear accumulation of the polyglutamine-expanded AR protein is central to the gender-specific pathogenesis of SBMA, although additional steps, e.g., DNA binding, inter-domain interactions, and post-translational modification of AR, modify toxicity. | polyglutamine | androgen receptor | Homo sapiens |
| 6 | The ligand-dependent nuclear accumulation of the polyglutamine-expanded AR protein is central to the gender-specific pathogenesis of SBMA, although additional steps, e.g., DNA binding, inter-domain interactions, and post-translational modification of AR, modify toxicity. | polyglutamine | androgen receptor | Homo sapiens |
| 7 | The interactions with co-regulators are another requisite for the toxic properties of the polyglutamine-expanded AR. | polyglutamine | androgen receptor | Homo sapiens |
| 8 | It is also shown that the polyglutamine-expanded AR induces diverse molecular events, such as transcriptional dysregulation, axonal transport disruption, and mitochondrial dysfunction, which play causative roles in the neurodegeneration in SBMA. | polyglutamine | androgen receptor | Homo sapiens |
| 9 | It is also shown that the polyglutamine-expanded AR induces diverse molecular events, such as transcriptional dysregulation, axonal transport disruption, and mitochondrial dysfunction, which play causative roles in the neurodegeneration in SBMA. | polyglutamine | androgen receptor | Homo sapiens |