Title : Effect of amiloride and spironolactone on renal tubular function, ambulatory blood pressure, and pulse wave velocity in healthy participants in a double-blinded, randomized, placebo-controlled, crossover trial.

Pub. Date : 2012

PMID : 22591021






2 Functional Relationships(s)
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1 We wanted to test the hypothesis that treatment with amiloride or spironolactone reduced ambulatory (ABP) and central blood pressure (CBP) and that tubular transport via ENaCgamma and AQP2 was increased after furosemide treatment. Furosemide aquaporin 2 Homo sapiens
2 The increases in water and sodium absorption via AQP2 and ENaC after furosemide treatment most likely are compensatory phenomena to antagonize water and sodium depletion. Furosemide aquaporin 2 Homo sapiens