Pub. Date : 2012 Jun 15
PMID : 22583617
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity. | GW 4064 | ATP binding cassette subfamily B member 11 | Homo sapiens |
2 | E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity. | GW 4064 | ATP binding cassette subfamily B member 11 | Homo sapiens |
3 | We previously found that compounds based on GW4064, a representative farnesoid X receptor (FXR) agonist, enhanced E297G BSEP transport activity. | GW 4064 | ATP binding cassette subfamily B member 11 | Homo sapiens |
4 | Here, we conducted a structure-activity relationship analysis of GW4064 derivatives aimed at separating E297G BSEP-function-promoting activity and FXR-agonistic activity. | GW 4064 | ATP binding cassette subfamily B member 11 | Homo sapiens |
5 | Among newly synthesized reversed-amide derivatives of previously reported GW4064 analogs 2a-2f, we identified 7c as a selective BSEP function enhancer. | GW 4064 | ATP binding cassette subfamily B member 11 | Homo sapiens |