Title : Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones.

Pub. Date : 2012 Aug

PMID : 22581381






1 Functional Relationships(s)
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1 Estradiol, testosterone, progesterone and androstenedione inhibited BCRP-mediated uptake of (3)H-estrone sulphate (E(1)S) most potently, with calculated inhibitory constant (Ki) values of 5.0 +- 0.2, 36 +- 14, 14.7 +- 1.3 and 217 +- 13 muM, respectively. Progesterone latexin Homo sapiens