Title : Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation.

Pub. Date : 2012 Aug

PMID : 22579702






2 Functional Relationships(s)
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1 Interestingly, the population of human IL-17(+)IFN-gamma(-) CD4 T cells or IL-17(+)TNF-alpha(+) CD4 T cells were decreased by adding of tacrolimus. Tacrolimus tumor necrosis factor Homo sapiens
2 Tacrolimus also inhibited expression of IL-17 or TNF-alpha by reducing the proportion of Th17, suggesting that therapeutic effect on Th17-associated disease such as RA, inflammatory bowel disease, multiple sclerosis, psoriasis, or allograft rejection. Tacrolimus tumor necrosis factor Homo sapiens