Title : A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells.

Pub. Date : 2012 Jul

PMID : 22579584






1 Functional Relationships(s)
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1 We demonstrate that knockdown of ELOVL1 or CERS2, which catalyze synthesis of C24 acyl-CoAs and C24 ceramide, respectively, drastically reduced C24 sphingolipid levels with a complementary increase in C16 sphingolipids. Acyl Coenzyme A ELOVL fatty acid elongase 1 Homo sapiens