Pub. Date : 2012
PMID : 22576470
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of cultured THP-1 macrophages in vitro with candesartan resulted in a similar decrease in ACAT1 expression. | candesartan | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 2 | In the kidney, glomerular lipid accumulation, mesangial expansion, and albuminuria were significantly regressed after treatment with high-dose candesartan, while biglycan and ACAT1 expressions were decreased. | candesartan | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 3 | CONCLUSION: These results suggest that regression of established atherosclerosis lesions in ApoE-deficient mice is feasible using high-dose candesartan, by mechanisms involving (i) a decrease in the lipid-retaining proteoglycan biglycan, and (ii) suppression of ACAT1 expression resulting in increased free cholesterol for lipid release. | candesartan | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |