Title : GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.

Pub. Date : 2012 Jul

PMID : 22573891






1 Functional Relationships(s)
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1 Here we show that GBF1, a guanine nucleotide exchanging factor for Arf-GTPases, is primarily responsible for Arf1 activation upon GPCR stimulation and is important for neutrophil chemotaxis and superoxide production. Guanine Nucleotides golgi brefeldin A resistant guanine nucleotide exchange factor 1 Homo sapiens