Pub. Date : 2012 Dec
PMID : 22571166
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to explore the effects, as well as the signaling pathway, of nicotine and lipopolysaccharide (LPS) on the expression of HIF-1alpha and on the production of its target genes, including cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2) ), MMP-2 and MMP-9 in PDLCs. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | The aim of this study was to explore the effects, as well as the signaling pathway, of nicotine and lipopolysaccharide (LPS) on the expression of HIF-1alpha and on the production of its target genes, including cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2) ), MMP-2 and MMP-9 in PDLCs. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | RESULTS: LPS and nicotine synergistically induced the production of PGE(2) , MMP-2 and MMP-9, and increased the expression of MMP-2, MMP-9, COX-2 and HIF-1alpha proteins. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Inhibition of HIF-1alpha activity by chetomin or knockdown of HIF1alpha gene expression by small interfering RNA markedly attenuated the production of LPS- and nicotine-stimulated PGE(2) and MMPs, as well as the expression of COX-2 and HIF-1alpha. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | Furthermore, pretreatment with inhibitors of COX-2, p38, extracellular signal-regulated kinase, Jun N-terminal kinase, protein kinase C, phosphatidylinositol 3-kinase and nuclear factor-kappaB decreased the expression of nicotine- and LPS-induced HIF-1alpha and COX-2, as well as the activity of PGE(2) and MMPs. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | Furthermore, pretreatment with inhibitors of COX-2, p38, extracellular signal-regulated kinase, Jun N-terminal kinase, protein kinase C, phosphatidylinositol 3-kinase and nuclear factor-kappaB decreased the expression of nicotine- and LPS-induced HIF-1alpha and COX-2, as well as the activity of PGE(2) and MMPs. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |