Title : Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19.

Pub. Date : 2012 Oct

PMID : 22561792






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid nuclear receptor subfamily 1 group I member 2 Homo sapiens
3 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid nuclear receptor subfamily 1 group I member 2 Homo sapiens
4 Lithocholic acid (LCA) (10 muM), chenodeoxycholic acid (CDCA) (10 muM), or GW4064 (0.1 muM) treatment increased reporter activity in a construct including the three motifs under FXR-expressing conditions whereas LCA and not CDCA or GW4064 treatment increased the reporter activity under pregnane X receptor (PXR)-expressing conditions. Lithocholic Acid nuclear receptor subfamily 1 group I member 2 Homo sapiens