Title : Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo.

Pub. Date : 2012 Jun

PMID : 22561688






3 Functional Relationships(s)
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1 Mechanistically, we found that both nicotine and AngII activated AMPK-alpha2 in cultured vascular smooth muscle cells (VSMCs), resulting in the phosphorylation of activator protein 2alpha (AP-2alpha) and consequent matrix metallopeptidase 2 (MMP2) gene expression. Nicotine matrix metallopeptidase 2 Mus musculus
2 Mechanistically, we found that both nicotine and AngII activated AMPK-alpha2 in cultured vascular smooth muscle cells (VSMCs), resulting in the phosphorylation of activator protein 2alpha (AP-2alpha) and consequent matrix metallopeptidase 2 (MMP2) gene expression. Nicotine matrix metallopeptidase 2 Mus musculus
3 We conclude that smoking (through nicotine) instigates AAA through AMPK-alpha2-mediated AP-2alpha-dependent MMP2 expression in VSMCs. Nicotine matrix metallopeptidase 2 Mus musculus