Title : Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.

Pub. Date : 2012 Jul 15

PMID : 22555846






1 Functional Relationships(s)
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1 IS promoted protein expression of p53, p21, and senescence-associated beta-galactosidase (SA-beta-gal) activity in HASMCs, and N-acetylcysteine and pifithrin-alpha,p-nitro, a p53 inhibitor, blocked these effects. hasmcs Wistar clone pR53P1 p53 pseudogene Rattus norvegicus