Pub. Date : 2012 Jul
PMID : 22552582
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that green tea polyphenols (GTPs) and their major constituent, (-) epigallocatechin-3-gallate (EGCG), activate p53 through acetylation at the Lys373 and Lys382 residues by inhibiting class I HDACs in LNCaP human prostate cancer cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 2 | In this study, we demonstrate that green tea polyphenols (GTPs) and their major constituent, (-) epigallocatechin-3-gallate (EGCG), activate p53 through acetylation at the Lys373 and Lys382 residues by inhibiting class I HDACs in LNCaP human prostate cancer cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 3 | In this study, we demonstrate that green tea polyphenols (GTPs) and their major constituent, (-) epigallocatechin-3-gallate (EGCG), activate p53 through acetylation at the Lys373 and Lys382 residues by inhibiting class I HDACs in LNCaP human prostate cancer cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 4 | Discontinuation of treatment with GTP/EGCG resulted in the loss of p53 acetylation at both the sites in these cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 5 | Discontinuation of treatment with GTP/EGCG resulted in the loss of p53 acetylation at both the sites in these cells. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 6 | The increased GTP/EGCG-mediated p53 acetylation enhanced its binding on the promoters of p21/waf1 and Bax, which was associated with increased accumulation of cells in the G0/G1 phase of the cell cycle and induction of apoptosis. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 7 | The increased GTP/EGCG-mediated p53 acetylation enhanced its binding on the promoters of p21/waf1 and Bax, which was associated with increased accumulation of cells in the G0/G1 phase of the cell cycle and induction of apoptosis. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 8 | Our findings indicate that GTP/EGCG causes acetylation of p53 by inhibiting class I HDACs, a function that is likely to be part of the mechanisms that control the physiological activity of p53. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 9 | Our findings indicate that GTP/EGCG causes acetylation of p53 by inhibiting class I HDACs, a function that is likely to be part of the mechanisms that control the physiological activity of p53. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 10 | Our findings indicate that GTP/EGCG causes acetylation of p53 by inhibiting class I HDACs, a function that is likely to be part of the mechanisms that control the physiological activity of p53. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 11 | Our findings indicate that GTP/EGCG causes acetylation of p53 by inhibiting class I HDACs, a function that is likely to be part of the mechanisms that control the physiological activity of p53. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |