Title : Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.

Pub. Date : 2012 Nov

PMID : 22552008






2 Functional Relationships(s)
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1 Our studies demonstrate that thalidomide, lenalidomide and another immunomodulatory drug, pomalidomide, bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. Lenalidomide damage specific DNA binding protein 1 Homo sapiens
2 Our studies demonstrate that thalidomide, lenalidomide and another immunomodulatory drug, pomalidomide, bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. Lenalidomide damage specific DNA binding protein 1 Homo sapiens