Pub. Date : 2012 Aug
PMID : 22551668
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. | Cholesterol | beta-secretase 1 | Homo sapiens |
| 2 | We previously reported that cholesterol accumulation in NPC-cells leads to cholesterol-dependent increased APP processing by beta-secretase (BACE1) and decreased APP expression at the cell surface (Malnar et al. | Cholesterol | beta-secretase 1 | Homo sapiens |
| 3 | We previously reported that cholesterol accumulation in NPC-cells leads to cholesterol-dependent increased APP processing by beta-secretase (BACE1) and decreased APP expression at the cell surface (Malnar et al. | Cholesterol | beta-secretase 1 | Homo sapiens |
| 4 | We hypothesized that increased formation of APP-CTFs and Abeta in NPC disease is due to cholesterol-mediated altered endocytic trafficking of APP and/or BACE1. | Cholesterol | beta-secretase 1 | Homo sapiens |
| 5 | Moreover, we observed that NPC cells show cholesterol dependent sequestration and colocalization of APP and BACE1 within enlarged early/recycling endosomes which can lead to increased beta-secretase processing of APP. | Cholesterol | beta-secretase 1 | Homo sapiens |
| 6 | Our findings suggest that increased cholesterol levels, such as in NPC disease and sporadic AD, may be the upstream effector that drives amyloidogenic APP processing characteristic for Alzheimer"s disease by altering endocytic trafficking of APP and BACE1. | Cholesterol | beta-secretase 1 | Homo sapiens |