Title : Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase.

Pub. Date : 2012 Oct

PMID : 22551156






3 Functional Relationships(s)
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1 We suggested that lack of Cav-1 modulated levels of COX-2 which in turn modulated tracheal contraction, when arachidonic acid signalling was disturbed by inhibition of COX-2. Arachidonic Acid cytochrome c oxidase II, mitochondrial Mus musculus
2 We suggested that lack of Cav-1 modulated levels of COX-2 which in turn modulated tracheal contraction, when arachidonic acid signalling was disturbed by inhibition of COX-2. Arachidonic Acid cytochrome c oxidase II, mitochondrial Mus musculus
3 CONCLUSION AND IMPLICATIONS: The indomethacin-induced hypercontractility observed in Cav-1 KO tracheas was linked to increased expression of COX-2 and 5-LO, which probably enhanced arachidonic acid shunting and generation of pro-contractile leukotrienes when COX-2 was inhibited. Arachidonic Acid cytochrome c oxidase II, mitochondrial Mus musculus