Pub. Date : 2012 May 15
PMID : 22550179
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Application of OSS (0.5 +- 4 dyn/cm(2)) causes the sustained activation of Smad1/5 in ECs through activations of mammalian target of rapamycin and p70S6 kinase, leading to up-regulation of cyclin A and down-regulations of p21(CIP1) and p27(KIP1) and, hence, EC cycle progression. | OSS | SMAD family member 1 | Homo sapiens |
| 2 | Immunohistochemical and en face examinations of the experimentally stenosed abdominal aorta in rats show high levels of phospho-Smad1/5 in ECs at poststenotic sites, where OSS occurs. | OSS | SMAD family member 1 | Homo sapiens |
| 3 | Transfecting ECs with Smad1/5-specific small interfering RNAs inhibits the OSS-induced EC cycle progression. | OSS | SMAD family member 1 | Homo sapiens |