Title : AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells.

Pub. Date : 2012 Jun 15

PMID : 22550166






2 Functional Relationships(s)
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1 In contrast, the recruitment of the ERalpha/AIB1 transcriptional complex to the nonclassic ER target cyclin D1 and its subsequent expression remained sensitive to steroid treatment and could be inhibited by treatment with letrozole. Steroids cyclin D1 Homo sapiens
2 Molecular studies revealed that this may be due in part to direct steroid regulation of c-jun-NH(2)-kinase (JNK), signaling to Jun and Fos at the cyclin D1 promoter. Steroids cyclin D1 Homo sapiens