Pub. Date : 2012 Aug 30
PMID : 22546501
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine stimulated bone marrow-derived dendritic cells could augment HBV specific CTL priming by activating PI3K-Akt pathway. | Nicotine | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | The results showed that: first, the maximal activation of PI3K and Akt was reached at 30 and 60-120 min respectively after nicotine stimulation. | Nicotine | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Nicotine up-regulated the expression of alpha7 nAChR by activating PI3K-Akt pathway in murine DCs; secondly, nicotine stimulation could enhance DCs" ability of HBV-specific T cell proliferation and IL-12 secretion; thirdly, adoptive transfer of nicotine stimulated DCs could induce HBV specific CTL priming in vivo and those CTL had cytolytic activities; fourthly, nicotine had equal efficiencies to 2 ng/ml IFN-gamma in DCs-mediated T cell proliferation. | Nicotine | thymoma viral proto-oncogene 1 | Mus musculus |