Title : Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α.

Pub. Date : 2012 Apr 26

PMID : 22537532






1 Functional Relationships(s)
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1 In particular, simvastatin was less effective in PPAR-alpha KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation, neutrophil infiltration, nitrotyrosine formation, pro-inflammmatory cytokine expression, nuclear factor (NF)-kappaB activation, inducible nitric-oxide synthase (iNOS) expression, and apoptosis. Simvastatin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus