Title : Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells.

Pub. Date : 2012 Apr 26

PMID : 22537194






1 Functional Relationships(s)
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1 Pemetrexed (Alimta , MTA) is a multitarget antifolate that inhibits folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, required for de novo synthesis of nucleotides for DNA replication. Folic Acid thymidylate synthetase Homo sapiens