Title : Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells.

Pub. Date : 2012 Apr 26

PMID : 22537194






2 Functional Relationships(s)
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1 We show that an increment of the intracellular reactive oxygen species (ROS) and p53 is required for MTA-induced cytotoxicity by utilizing N-Acetyl-L-Cysteine (NAC) to blockage of ROS and p53-defective H1299 NSCLC cell line. Acetylcysteine tumor protein p53 Homo sapiens
2 We show that an increment of the intracellular reactive oxygen species (ROS) and p53 is required for MTA-induced cytotoxicity by utilizing N-Acetyl-L-Cysteine (NAC) to blockage of ROS and p53-defective H1299 NSCLC cell line. Acetylcysteine tumor protein p53 Homo sapiens