Title : In vitro hepatotoxicity and cytochrome P450 induction and inhibition characteristics of carnosic acid, a dietary supplement with antiadipogenic properties.

Pub. Date : 2012 Jul

PMID : 22531045






3 Functional Relationships(s)
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1 Measuring cellular ATP, carnosic acid showed a dose-dependent increase in hepatotoxicity with an EC(50) value of 94.8 +- 36.7 muM in three human hepatocyte donors without a concurrent increase in the apoptosis markers caspase-3/7. salvin latexin Homo sapiens
2 In human liver microsomes, carnosic acid did not exhibit significant time-dependent inhibition for any of the cytochrome P450 enzymes investigated, although it did inhibit CYP2C9- and CYP3A4-catalyzed reactions with K(i) values of 9.2 and 4.3 muM, respectively. salvin latexin Homo sapiens
3 At 10 muM, carnosic acid increased CYP2B6 enzyme activity 61.6 and 49.3% in two donors compared with phenobarbital, and it increased CYP3A enzyme activity 82.6 and 142% compared with rifampicin. salvin latexin Homo sapiens