Title : Unravelling the reaction mechanism of the reductive ring contraction of 1,2-pyridazines.

Pub. Date : 2012 May 18

PMID : 22530929






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1 By establishing the need for electron-withdrawing resonant groups in the 3- and 6-positions to stabilize the critical intermediate in the initial stages of the reaction, this work suggests that the scope of the reductive ring contraction of 1,2-pyridazines may be expanded to pyridazines bearing COCH(3) groups, amides or aryls in these positions. Pyridazines cochlin Homo sapiens