Pub. Date : 2012 Jul
PMID : 22528119
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was recently shown that the antitumor activity of etoposide was due primarily to the inhibition of Top2alpha, whereas inhibition of Top2beta was responsible for the development of secondary malignancies, pointing to the need for more selective Top2alpha inhibitors. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 2 | We further confirmed that Top2alpha inhibition was due to a catalytic inhibition of the enzyme because it did not induce DNA double-strand breaks in CEM-treated cells but prevented the formation of Top2alpha- rather than Top2beta-DNA covalent complexes induced by etoposide. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 3 | We further confirmed that Top2alpha inhibition was due to a catalytic inhibition of the enzyme because it did not induce DNA double-strand breaks in CEM-treated cells but prevented the formation of Top2alpha- rather than Top2beta-DNA covalent complexes induced by etoposide. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |