Title : Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes.

Pub. Date : 2012

PMID : 22514710






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1 In conclusion, the results indicate that H(2)O(2) at low concentrations causes premature senescence in human keratinocytes by activating p53-p21(CIP1) signaling and that these effects can be prevented by acute AMPK activation and enhanced by AMPK downregulation. Hydrogen Peroxide tumor protein p53 Homo sapiens