Pub. Date : 2012 Jul
PMID : 22511543
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 2 | Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 3 | Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 4 | Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 5 | Ligation of M3R with CCh transactivated EGFR and phosphorylated ERK and Akt, the downstream targets of EGFR. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 6 | Ligation of M3R with CCh transactivated EGFR and phosphorylated ERK and Akt, the downstream targets of EGFR. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 7 | CCh stimulated Src phosphorylation and binding to EGFR. | Carbachol | epidermal growth factor receptor | Homo sapiens |